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Prevent Prostate Cancer

EGCG provides other benefits specific to prostate cancer prevention. A study published in the December 2004 issue of the International Journal of Cancer found that EGCG significantly inhibited, in a dose-dependent manner, the production of prostate-specific antigen (PSA), a marker for prostate cancer risk. Not only did EGCG lower PSA levels, but it also suppressed all the activities of PSA which were examined that promote prostate cancer.

Green tea polyphenols halt prostate cancer at multiple levels

The polyphenols in green tea help prevent the spread of prostate cancer by mobilizing several molecular pathways that shut down the proliferation and spread of tumor cells, while also inhibiting the growth of blood vessels that supply the cancer with nourishment, according to research published in the December 2004 issue of Cancer Research.

Green tea polyphenols:

  • decrease insulin-like growth factor-1 (IGF-1), while increasing levels of IGF binding protein-3, which binds IGF-1, further diminishing its activity. (Increased levels of IGF-1 are associated not only with prostate cancer, but cancers of the breast, lung and colon.)
  • inhibit key cell survival proteins, promoting apoptosis or programmed cell death in cancer cells.
  • reduce the expression of several compounds (urokinase plasminogen activator and matrix metalloproteinase 2 and 9) involved in the metastasis and spread of cancer cells.
  • reduce the amount of vascular endothelial growth factor (VEGF), which develops new blood vessels to carry nutrients to developing tumors.
All these effects were seen in this animal study within 6 months of continuous infusion. While obviously impractical for humans, the study suggests that daily consumption of green tea may be highly protective.
Choosing to regularly drink green tea and eat fruits and vegetables rich in the carotenoid, lycopene, may greatly reduce a man's risk of developing prostate cancer, suggests research published the Asia Pacific Journal of Clinical Nutrition (Jian L, Lee AH, et al.)

In this case-control study involving 130 prostate cancer patients and 274 hospital controls, men drinking the most green tea were found to have an 86% reduced risk of prostate cancer compared, to those drinking the least.

A similar inverse association was found between the men's consumption of lycopene-rich fruits and vegetables such as tomatoes, apricots, pink grapefruit, watermelon, papaya, and guava. Men who most frequently enjoyed these foods were 82% less likely to have prostate cancer compared to those consuming the least lycopene-rich foods.

Regular consumption of both green tea and foods rich in lycopene resulted in a synergistic protective effect, stronger than the protection afforded by either, the researchers also noted.

Practical Tips: Get in the habit of drinking green tea and eating lycopene-rich foods.

  • Take a quart of iced green tea to work and sip throughout the day or take it to the gym to provide prostate protection while replenishing fluids after your workout.
  • Pack a ziploc bag of apricots and almonds in your briefcase or gym bag for a handy snack.
  • Start your breakfast with a half grapefruit or a glass of papaya or guava juice.
  • Begin lunch or dinner with some spicy tomato juice on the rocks with a twist of lime. Snack on tomato crostini: in the oven, toast whole wheat bread till crusty, then top with tomato sauce, herbs, a little grated cheese, and reheat until the cheese melts.
  • Top whole wheat pasta with olive oil, pine nuts, feta cheese and a rich tomato sauce for lunch or dinner.
Drinking 5 cups of green tea a day may cut the risk of advanced prostate cancer in half, shows data collected in The Japan Public Health Center-based Prospective Study. The JPHC Study followed 49,920 Japanese men aged from 40 to 69 from 1990 to 2004. Compared to men who drank less than one cup of green tea per day, those consuming 5 or more cups daily reduced their risk of developing advanced prostate cancer by 48%! If you don't already drink green tea, consider making this energizing, delicious beverage a healthy habit. Over half a million new cases of prostate cancer are diagnosed each year world wide, and, incidence of the disease, which is the direct cause of more than 200,000 deaths annually, is increasing with a rise of 1.7% over 15 years.

 

 
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